Dietary supplement in soft gelatin capsule

Enabling Pharmaceutical Gel Capsule Formulations

Enhance your oral formulations with high quality ingredients

Consumers prefer gelatin capsules over other dosage forms, so the development of drugs in this form is more relevant than ever.

CARBOWAX™ SENTRY™ LPEG and MPEGs are pharmaceutical excipients which can be used in the manufacturing of capsules as hydrophilic fillers for solubilization of the Active Pharmaceutical Ingredient (API), but also as plasticizer in the coating of the gelatin capsules.

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CARBOWAX™ SENTRY™ Polyethylene Glycols (PEGs) have a long history of use in capsule formulations because they meet all compendial requirements and have the below benefits.

Lower molecular weight

Facilitating formulation of gelatin capsules when working with poorly soluble APIs.

Reduce risk of cross linking

Selecting our low aldehydes grades, helps reduce risk of cross linking of the shell.

Low impurity profiles

Allowing more consistent manufacturing and longer shelf-life of drugs.

Improved residual solvent profile

Lowering the Ethylene Glycol (EG) levels in your formulation.

Meet USP-NF and EP monographs

Offering regional regulatory and technical support for pharmaceutical applications.

LOW ALDEHYDE GRADES
CARRIERS/FILLERS
PLASTICIZERS
STABILIZERS

Available low aldehyde grades

Minimize cross linking of the gelatin shell:
- Low aldehyde and low ethylene glycol PEG 300
- Low aldehyde and low ethylene glycol PEG 400
- Low aldehyde and low ethylene glycol PEG 600
Maintain low EG levels throughout processing by following Dow’s simple handling guidance.

Carriers and filler

Improve the solubility of poorly soluble APIs by using:
- 5-50% CARBOWAX™ SENTRY™ PEG 300
- 5-50% CARBOWAX™ SENTRY™ PEG 400
- 5-50% CARBOWAX™ SENTRY™ PEG 600
Example poorly soluble APIs: Acyclovir.

Blue soft gel capsule medicine in strip package with blur background

Plasticizers

Improve the elasticity of the soft gelatin capsule shells:
- 5-30% CARBOWAX™ SENTRY™ PEG 300
- 5-30% CARBOWAX™ SENTRY™ PEG 400
- 5-50% CARBOWAX™ SENTRY™ PEG 600
- 5-30% CARBOWAX™ SENTRY™ PEG 1000
- 5-30% CARBOWAX™ SENTRY™ PEG 1450
The optimum quantity of the PEG in the formulation depends on the rest of the components. We recommend formulators to calculate their optimum dosage, and we are here to give guidance.

Stabilizers

Reduce degradation risks:
- – 1% VERSENE™ NA Edetate Disodium
EDTA prevents chemical degradation of oxidation sensitive drugs which process is catalyzed by free metals in gelatin, such as iron.